Blood Center/Blood Hospital-Based Donor Center
Eiman Hussein, MD, PhD
Cairo University, Faculty of Medicine, Department of Clinical and Chemical Pathology, Division of Transfusion Medicine
Cairo, Al Jizah, Egypt
An efficient plateletpheresis device collects large numbers of platelets in short times, while avoiding adverse events (AEs) and significant post- donation platelet drop. Typically, at our unit, patients’ friends and family members are motivated to donate, with priority given to males with platelets > 250 × 109 /L, and who weigh at least 85 Kg. The aim of this study was to evaluate factors that might influence platelet yields via 3 devices. Our hope was to maximize yields and ensure the most convenient and safe donation experience.
Study
Design/Methods:
A total of 300 sessions were studied on each device (Haemonetics Vs. Trima Vs. Optia). We investigated donors’ data, blood volume processed, anticoagulant used, procedure time, platelet yields and AEs. A total of 100 Donors on each device were also evaluated for post-apheresis platelet and hematocrit drop.
Results/Findings:
All donors were males and their median age was 27 years.
Haemonetics encountered 13 AEs (4.3%), including vasovagal events in 6 donors, machine problem in five donors and vein problem in 2 donors. Seven donors on Trima had vasovagal events (2.3%), after a platelet yield of 6 x1011 was collected from two donors. Two vasovagal events occurred with Optia (0.7%).
Platelet yields of 10-12 x1011 were collected from significantly larger numbers of Trima donors, despite having significantly lower platelet counts, when compared with those on Optia p< 0.05.
Session time, donors’ weight and pre-session platelet counts positively impacted platelet yields with Haemonetics p< 0.05. Higher platelet yields of >9 x1011 were influenced by donors’ weight on both Optia and Trima p< 0.05. Compared with Haemonetics, both Optia and Trima collected significantly higher platelet yield, in significantly less time, using less citrate and processing smaller blood volumes P< 0.05.
The impact of donors’ Data and session time on platelet yields obtained by Optia, Trima and Haemonetics are shown in Table 1.
Post-apheresis platelet and hematocrit drop were not influenced by platelet pre-count, platelet yield, collecting device or by session time P >0.05. Platelet drop was variable among different donors with a median of 64 × 109 /L (25 × 109 /L-145× 109 /L). Percent platelet drop ranged from 12-62% with a median of 31% and none of the donors had platelets of < 140 × 109 /L.
The median drop of hematocrit was 3% (0- 4.5%)
Conclusions:
Increasing processing time for donors, with platelet counts of >280×109 /L, and who weigh at least 85 Kg, can increase platelet yields on Haemonetics.
Compared with Haemonetics, the Optia and Trima seem to collect larger numbers of platelets (9 x1011 vs 5.7 x1011), in significantly less time, while maintaining safety of donors. Higher yields were obtained via Trima and lower AEs were observed with Optia.
This can ultimately provide effective utilization of those expensive kits, while ensuring a safe and pleasant donation experience.