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Hematology and Coagulation

(P-HC-10) Coagulopathy and transfusion challenges encountered with the first cohort of liver transplant surgeries in Oman

Sunday, October 20, 2024
12:00 PM - 1:00 PM  
Background/Case Studies: The Royal Hospital is the only centre in Oman in which liver transplant surgeries are performed. Blood product management during liver transplant surgeries is guided by the use of TEG. Between January 2017 and September 2023, thirty liver transplant surgeries have been performed at the Royal Hospital. 

In this study, we aimed to review data of these 30 cases to understand and evaluate the coagulopathy, transfusion requirements and outcomes of these patients.

Study

Design/Methods:

After approval, a retrospective cohort study was conducted in which all patients who underwent liver transplant surgeries at the Royal Hospital were included. Data was analysed descriptively. This study is planned to continue prospectively, after which more sophisticated outcome analysis will be attempted once the sample size becomes larger.

Results/Findings:

30 patients were included, of which 17 were females. Median age was 50 (IQR: 31.5 – 58.5). Table 1 shows the coagulation parameters intra-operatively and 24 hours post-operatively, as well as the intra-operative and 24 post-operative transfusion requirements. The median number of days in the ICU was 4.5 days (range: 3 – 15) and the median number of days to discharge was 16 days (range: 7 – 80). No mortality and no thrombotic events were observed. Bleeding occurred in two of the patients.

Conclusions:

In our cohort, we observed modest requirement of blood products intra-operatively and 24 hours post-operatively with favourable outcomes. This is perhaps because most of the cases are of low risk profile. The prospective part of this analysis will be of great value.