(P-TS-12) Analysis Of Immediate And Delayed Adverse Events In Voluntary Plateletpheresis Donors Associated With Plateletpheresis Procedure

The plateletpheresis procedures are well tolerated but adverse events (AEs) of variable severity may occur during or after the procedure. It is important to identify AEs and the risk factors associated with plateletpheresis procedures. The study aimed to analyze the frequency of immediate adverse events (IAE) and delayed adverse events (DAE) in plateletpheresis procedures and the factors associated with them.

Study

Design/Methods:

This was a prospective observational study done in a tertiary care oncology centre over a period of 3 months after the approval of the Institutional Ethics Committee and registration under Clinical Trial Registry of India. Total of 1000 consecutive voluntary repeat plateletpheresis donors as per the eligibility criteria were included after obtaining informed consent. AEs experienced by the donor during or immediately after the procedure were considered as IAE. The donors were contacted telephonically between 6^th to 8^th day of plateletpheresis and a self-structured questionnaire was used to obtain information. All IAEs and DAEs further analysed as citrate-related, vasovagal, venipuncture-related, or allergic. Appropriate statistical tests were applied for analysis.


Results/Findings:

Total of 1000 procedures were conducted in 504 repeat platelet donors of which 456 donors responded to the telephonic call for 953 procedures. Hence, an evaluation of 953 procedures was done. AEs were reported in 42.1% (401/953) of procedures. Analysis of these 401 procedures showed that 264 were only IAEs, 55 were only DAEs and 82 were both AEs, thus total IAEs were 346 and total DAEs were 137.  The overall frequency of immediate, delayed, and both types of AEs in the entire study sample was found to be 27.7% (264/953), 5.8% (55/953), and 8.6% (82/953) respectively. The majority of IAEs were citrate reactions while the majority of DAEs were venipuncture-related. First-time donation status, female gender, and history of AEs during previous plateletpheresis showed a significant correlation (p< 0.05). (Table 1)

Conclusions:

The occurrence of delayed AEs highlights the need for proactive follow-up of all donors. Implementing post-donation telephonic follow-up could be an efficient tool for gathering information systematically. Plateletpheresis donors represent a special pool of altruistic donors; prioritizing donor care could significantly contribute to donor retention.