Professor of Pathology and Medicine and Medical Director
University of Maryland School of Medicine, Maryland, United States
My research interest is at the frontier of transfusion medicine and cellular therapies. My contributions to the field of transfusion medicine are in the management of the blood supply chain and prevention of transfusion adverse events. Transfusion of blood products is beneficial for hemato-oncologic patients but can lead to serious immunologic reactions such as alloimmunization and immunomodulation. In order to improve the management of these reactions, my laboratory studies the activation profiles of blood leukocyte subsets, in patients with or without a history of transfusion reactions. Platelet and red blood cell interactions are explored as playing a role as well in regulating leukocyte activation during the blood transfusion process. We use the standard immunohematology indirect antiglobulin test, based on red blood cell agglutination, as well as flow cytometry based methods, to characterize the expression of red cell surface antigens during erythropoiesis and to test the function of these glycoprotein antigens in leukocyte and platelet interaction.
Monday, October 21, 2024
2:00 PM - 3:00 PM
Disclosure(s): No financial relationships to disclose