Oral Abstract - Mouse Models

Tuesday, October 22, 2024

10:30 AM - 11:30 AM

Location: 342

CE: 0 CME (AMA Physician Credit) / 1 CE (Non-Physician Credit)

Program Chair(s)

Understand the role of the expression of CD47 on transfused RBC in regulating antibody-mediated RBC clearance and RBC antigen loss in a mouse model and its potential implications on improving transfusion outcomes
Evaluate the safety and efficacy of performing leukapheresis using controlled incremental filtration, a method using microfluidics to separate cells by size, on human whole blood samples in vitro and in rats in vivo
Examine the kinetics of monoclonal anti-Duffy antibody binding and release from Duffy-expressing RBCs in vitro and in vivo using a mouse model and their potential implications for transfusion

10:30 AM - 11:30 AM

CD47 Expression on Transfused RBCs Impacts Antibody-Mediated Clearance and Antigen Loss in a Mouse Model
Presenting Author: Ryan P. Jajosky, MD – Brigham and Women's Hospital
10:30 AM - 11:30 AM

Microfluidic Leukapheresis is Safe and Effective in a Rat Model
Presenting Author: Sergey S. Shevkoplyas, PhD – University of Houston
10:30 AM - 11:30 AM

Rapid Association and Dissociation of a Monoclonal anti-Duffy Antibody to Duffy Expressing Red Blood Cells in a Mouse Model
Presenting Author: Ryan P. Jajosky, MD – Brigham and Women's Hospital