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Immunohematology and Genetic Testing (red cells, leukocytes and platelets)

Oral Abstract - Genomics

Tuesday, October 22, 2024
10:30 AM – 11:30 AM  
Location: 362
CE: 0 CME (AMA Physician Credit) / 1 CE (Non-Physician Credit)

    Program Chair(s)

  • Margaret Keller, PhD (she/her/hers)

    Executive, National Laboratories Senior Director, American Rare Donor Program American Red Cross
    American Red Cross
    Philadelphia, Pennsylvania, United States

    Disclosure(s): No financial relationships to disclose

    PDF

  • Patricia Brunker, MD, DPhil (she/her/hers)

    Medical Director, Blood Transfusion Service Patient Services
    Massachusetts General Hospital, Massachusetts, United States

    Disclosure(s): No financial relationships to disclose

    PDF
Disclosure(s):
Margaret A. Keller, PhD: No financial relationships to disclose
Patricia Brunker, MD, DPhil: No financial relationships to disclose

Learning Objectives:

  • Understand how molecular methods can be used to investigate ABO serologic discrepancies can uncover coding and non-coding variants that alter antigen expression.
  • Examine the use of large-scale genotyping of single nucleotide variants in red cell, platelet and leukocyte antigens can accurately and efficiently predict blood donor phenotypes.
  • Evaluate how next generation sequencing can identify tandem RHD alleles that would likely be missed by lower resolution molecular methods,

Presentations:

  • 10:30 AM – 11:30 AM  
    ABO*AW.09 is a common ABO subgroup involved in ABO discrepancies in US patients and blood donors

    Presenting Author: Ella Massie-Schuh, MS (she/her/hers) – American Red Cross

  • 10:30 AM – 11:30 AM  
    Four Novel ABO Enhancer Variants in Patients With Altered Phenotypes

    Presenting Author: June J. Fuertes, MLS(ASCP) (he/him/his) – New York Blood Center Enterprises

  • 10:30 AM – 11:30 AM  
    Real-World Feasibility of a Universal Blood Donor Typing Array for Large-Scale Genotyping of Red Cell, Platelet, and Leukocyte Antigens in an International Multi-Ethnic Donor Cohort

    Presenting Author: William J. Lane, MD, PhD, A(ACHI) – Brigham and Women's Hosptial

  • 10:30 AM – 11:30 AM  
    Targeted Quantitative NGS Uncovers 5 RH Alleles in Two Unrelated Patients, With DAU6 and Pseudogene in a Possible Tandem Arrangement

    Presenting Author: Sunitha Vege, MS – New York Blood Center